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Quick Answer: GLP-1 medications may not work as expected due to inadequate dosage, incorrect administration technique, insufficient treatment duration, lifestyle factors, concurrent medications, advanced beta-cell dysfunction, or unrealistic expectations about timeframes and outcomes
When they are depleted, even simple daily tasks can feel exhausting
Interestingly, even heterozygous Bbs5 +/ mice, which displayed normal body composition and energy metabolism compared with WT controls (Supplemental Figure 1, KV), were resistant to leptin (Supplemental Figure 3, K, L, O, and P), suggesting that leptin resistance may serve as a potential biomarker even in individuals with a single Bbs gene mutation
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