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References Wilding JPH, Batterham RL, Davies M, et al

The genetic test may help identify patients at higher risk for rapid weight regain by assessing appetite-regulation and fat-mass predisposition pathways

For example, in the STEP 1 trial extension, patients who stopped semaglutide after 68 weeks of treatment regained about two thirds of the weight they had lost within one year of discontinuation

Because the response is a protocol change, it belongs in a conversation with the provider supervising the taper

The full report is presented on a personalized web page with identifying information excluded that can easily be shared with their provider or family to discuss treatment options

What happens if I try to taper off and regain weightcan I restart GLP-1 therapy