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The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism

10.1016/j.cmet.2010.11.015 Cell Metab

This is the single most important distinction to understand

Invisible to HPLC and mass spec

Neuron 70 , 589596 (2011)

however, there are no guarantees or representations that a patient will receive any reimbursement