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[169] Some patients may require chronic treatment for persistent sleep disorders, while others may benefit from intermittent or seasonal use

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Longitudinal tumour growth was assessed using a joint modelling approach from the Jmbayes2 package (version 0.3-1), which incorporates survival data and mixed linear modelling for longitudinal tumour growth to account for missing not at random (MNAR) data at timepoints where animals have been removed from the study due to ethical endpoints related to maximum tumour size