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Many research protocols involve administration before bed

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In addition to facilitating WAT browning through multiple signaling pathways, GPER also suppresses inflammatory responses within WAT, fostering a microenvironment conducive to browning and increasing the overall metabolic rate [10]

Strategies for manipulating the microbiota include the use of prebiotics, administration of probiotics, fecal microbiota transplantation (FMT) for bacterial recolonization, and antimicrobial treatments to eliminate harmful pathogens or optimize specific bacterial populations

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