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In melanoma, ICIs such as ipilimumab and pembrolizumab are first-line treatments for advanced disease

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(11) P Dick, C Costa, K Fayolle, M E Grandjean, A Khoshbeen, and R Tissot (1984) DSIP in the treatment of withdrawal syndromes from alcohol and opiates European Neurology, 1984, Volume 23 (Issue 5), Pages 364-71

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Target engagement was confirmed by decreased phospho-tyrosine and NFT burden