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Originally isolated from the brain, DSIP is of particular interest in research on sleep patterns, circadian rhythm modulation, and stress adaptation mechanisms

C., Xie, B

others find it disruptive initially

Related Ang IV analogues were studied as well, such as Nle-Ang IV 2 (Nle-Tyr-Ile-His-Pro-Phe) and the endogenous LVV-hemorphin-7 3 (Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe), both with structural similarities to Ang IV at the N-terminal part of the peptides (Figure 1)

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