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Spermatozoa concentration and motility were counted in triplicate before and immediately after the addition of NEP inhibitors (opiorphin, phosphoramidon, and thiorphan)

While M1-activated microglia are indeed associated with cytotoxic responses through mechanisms such as nitric oxide release, M2 cells promote tissue repair via secretion of trophic factors like IGF-1, GDNF, and transforming growth factor- [469471]

The review emphasizes that clinical evidence is still evolving and requires more robust investigation

Further animal and in vitro studies suggest that epithalon may inhibit breast adenocarcinoma, linked to its telomerase activity [5]

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