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It is worth noting that the variability in agonist responses observed across different KO models may stem from differences in assay sensitivity, islet responsiveness and the physiological status of the mice, which can influence hormone responsiveness

Supplementing it orally, at standard doses, is unlikely to stress the liver

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Conjugation refers to the addition or coming together of compounds in order to neutralize toxins, making them more easily excreted through the urine or bile