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Given that BSO possesses non-specific pharmacological activities, the authors concluded that this effect was independent of the inhibition of GSH biosynthesis 15

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Many arginase inhibitors with high affinity have been developed over the past several decades, such as N-hydroxy-L-arginine [NOHA, K i = 3.6 M for human ARG1 (Di Costanzo et al., 2010), 1.6 M for human ARG2 ( d = 0.47 M for human ARG1 (Di Costanzo et al., 2010), 51 nM for human ARG2 ( 50 values of derivatives range 171,470 nM for human ARG1, 302,150 nM for human ARG2 (Ilies et al., 2011)] and S-(2-boronoethyl)-l-cysteine (BEC) [K i = 0.40.6 M (Pudlo et al

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They help convert environmental opportunities into usable metabolic substrates, including plant-derived carbohydrates such as glucose, and they thereby support both immediate survival and longer-term reproductive success [9]