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second, as a substrate for the production of hydrogen sulphide (H 2 S), which feeds the mitochondrial electron transfer chain and mediates per-sulphidation of ATPase and glycolytic enzymes, thereby stimulating cellular bioenergetics
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Molecular & Cellular Proteomics 13 , 25132526 (2014)
Whiteman, M
One main aspect is the choice of AAV serotype and capsid engineering to reach natural tropism
A 2016 study published in Nature Scientific Reports showed GHK-Cu produced no cytotoxicity to human keratinocytes at concentrations up to 5,800 micromolar over 72 hours and did not induce inflammatory biomarkers unlike other copper compounds
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