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10.1016/j.physbeh.2011.04.014 22 EvansS

These findings support the hypothesis of independent GSH regulation within the nucleus, also indicating that GSH transport might go through an active transport mechanism to achieve GSH enrichment in the nucleus, rather than free diffusion

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In contrast, Melanotan 2 is a shorter, cyclized (ring-shaped) peptide, which fundamentally alters its receptor binding properties

2.2 Clinical diagnosis To date, there is a lack of established diagnostic standards for BIPN, which leads to a frequent underestimation due to patient underreporting and insufficient assessment by physicians (Park et al., 2019)