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The approximately 4,000-gene figure is the headline quantitative claim and originates from Pickart & Margolina's 2018 work
Anim Sci 88:489499 Moriya J, Chen R, Yamakawa J-I et al (2011) Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells
Continuous lipid accumulation impairs mitochondrial function and elevates ROS production, 64 leading to lipid peroxidation, DNA damage, and protein denaturation, collectively initiating oxidative stress, inflammatory signaling, and hepatocellular injury
10.1016/j.conb.2009.05.001 3
