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This locus is situated within 1 Mb of previously associated POAG variants found in previous GWAS 54 , although these variants were suggested to regulate different genes

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GPXs have a greater affinity for H 2 O 2 (Km 1 M) than catalase (Km 1 mM) and are considered the principal enzymes responsible for eliminating H 2 O 2 that typically occurs in the low micro- and submicromolar range

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The two mutated mouse models represent an unbound form of IGF-1 with impaired post-translational control and increased bioavailability