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In contrast, cAMP signaling in response to GLP-1 was comparable between wild-type and mutant receptors, supporting the hypothesis that altered signaling with PF-06882961 was not due to a marked alteration of surface expression for the mutated constructs (Fig

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Polyunsaturated fatty acids and their metabolites play physiological roles: energy provision, membrane structure, fluidity, flexibility and selective permeability of cellular membranes, and cell signaling and regulation of gene expression (Catala, 2006)