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To summarize, it appears that HB can increase the UCP protein expression in the brain, while C10 may potentially activate UCPs to increase the proton leak (Figure 2)

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doi: 10.3389/fcdhc.2025.1590530 Received 09 March 2025 Accepted 18 June 2025 Published 10 July 2025 Volume 6 - 2025 Edited by Angelo Maria Patti, University of Palermo, Italy Reviewed by Anapaula Sommer Vinagre, Federal University of Rio Grande do Sul, Brazil Jun Eguchi, Okayama University, Japan Updates Copyright 2025 Hammad, Zafar, Ullah, Faisal, Iftikhar, Waheed, Muzaffar, Ahmed, Ashraf, Zahid, Akhtar and Mahmmoud Fadelallah Eljack

The inclusion of detailed clinical, economic, and retreatment-specific assumptions provides a more realistic representation of long-term treatment trajectories in real-world practice