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Additionally, those with severe inflammatory bowel disease (Crohn's disease or ulcerative colitis) may experience worsening diarrhea, nausea, or abdominal cramping, since GLP-1 agonists already cause gastrointestinal side effects in 3050% of users

Caffeine undergoes oxidative N-demethylation to produce main mono-demethylated metabolites like theophylline, theobromine, and paraxanthine [42,43]

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If diabetes is already present, oral health problems can make it much more difficult to control blood sugar, causing a compounding effect where both diabetes and oral issues get worse

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