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During lead optimization, less-sensitive cell assays are valuable for distinguishing the contributions of affinity and efficacy in the cellular response to an agonist ( 29 )

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BMI body mass index DPP dipeptidyl peptidase DPL DPP4-like protein FAP fibroblast activation protein GIP glucose-dependent insulinotropic polypeptide GLP-1 glucagon-like peptide-1 QPP quiescent cell proline dipeptidase SDF-1 Stromal cell-derived factor-1 T2DM type 2 diabetes mellitus