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The most recent comprehensive synthesis is a July 2025 systematic review in the HSS Journal , the musculoskeletal journal of the Hospital for Special Surgery in New York, led by Nikhil Vasireddi at Case Western Reserve University School of Medicine

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Tips for Managing an Early Dose If you and your provider have decided that taking a dose 24 hours early is appropriate for your situation, there are steps you can take to minimize the potential for discomfort