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Furthermore, previous studies have demonstrated that the simultaneous activation of the GLP-1R and the GIP-R results in enhanced glycaemic control, and lower HbA1c levels in human and rat, when compared with GLP-1R alone 53 , suggesting a GIP and GLP-1 synergism

Hoog MM, Vallarino C, Maldonado JM, Grabner M, Teng CC, Terrell K, Richard EL

48,5557 The AMPK-dependent pathways help in inhibiting gluconeogenesis by blocking the expression of genes of crucial enzymes like phosphoenolpyruvate carboxykinase, pyruvate carboxylase, and glucose 6 phosphatases that are responsible for gluconeogenesis

doi: 10.3945/jn.115.226621 21 BrosnanMEBrosnanJT

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W., Henshaw R