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In this cohort study, the use of GLP-1RAs, particularly semaglutide and tirzepatide, is associated with a lower incidence of dementia, stroke, and all-cause mortality in patients with both type 2 diabetes and obesity, suggesting potential neuroprotective and cerebrovascular benefits, Huan-Tang Lin, MD, PhD, and colleagues concluded

Together, they work synergistically

Dehydration and Electrolyte Imbalance : Gastrointestinal side effectsespecially nausea, vomiting, and diarrheacan lead to fluid and electrolyte losses

2018) and a phase 1 trial in PD dyskinesia showed partly positive results, but were limited by the short follow-up and small patient groups

Early in treatment, patients may notice mild changes in cravings, but the most consistent appetite reduction tends to emerge after several weeks of regular dosing