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The researchers adjusted dosages in subsequent experiments and found they could modulate the kidney impact

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And while the MTHFR variants primarily impact folate metabolism, the interconnectedness of the methylation cycle means that it indirectly affects vitamin B12 utilization as well

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[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Romeo S, Sentinelli F, Cambuli VM, Incani M, Congiu T, Matta V, et al