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If a pen accidentally freezes, it must be discarded and not used, as its safety and effectiveness cannot be guaranteed

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Nishida M, Ishikawa T, Saiki S, Sunggip C, Aritomi S, Harada E, Kuwahara K, Hirano K, Mori Y, Kim-Mitsuyama S (2013) Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice

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doi: 10.1074/jbc.M109.059246

After removing the needle, hold gentle pressure with a clean cotton pad for a few seconds if you notice any bleeding or leakage